The Final Frontier of Anti Aging | Joe Rogan & David Sinclair

Well, your concern is anti-aging. You certainly want people to live longer, but you yourself are more concerned with your work than you are with your own personal life. Oh, 100% my wife will tell you that. The reason that I look after myself as best I can when I've got the energy is it would be a bad look if I died from heart disease tomorrow. Yes, the anti-aging guy. Well, if you died from anything other than an accident. Right. Yeah. All right. So I'm trying to be a role model for others. But if I died tomorrow, that'd be fine with me. I'd like to finish my work at least. I would like to leave something behind. But what I don't want to do is to be a burden on my kids and my grandkids. And so that's what I'm also trying to prevent. Yeah, that would seem to me to be the real final frontier of anti-aging is folks that are really, really old because it seems like they would be open to try almost anything. And if you could bring them back, that would be uber bizarre. Right. How far away do you think we are from doing something like that? Well, it often comes as a shock to people who don't work on this that we're already testing these molecules in clinical trials on elderly people. I've been doing that for a number of years now with some positive results. Over at Harvard, we were giving NMN and another molecule called MIB626. What's the other one called? My laundry list. So the company's called Metro Biotech, and it makes super NAD boosters. And the drug is called developmental drug is MIB-626. 626. Yeah. And we're hoping that it will not just rejuvenate them. Do you have to give that in an alleyway somewhere? I got to go to some shady doctor with a weird accent. That one we hoped to get on the market in about three years from now. Really? Yeah, for diseases. FDA approved. And so they're using it right now on old folks? Testing it for safety. Yeah. But we're also going to be testing later energy. We can measure actually the NAD levels, that molecule I just mentioned. We can measure that in their muscles, and we'll test if that worked. And we'll measure, of course, their endurance, because the mice that we treated with NMN, they just ran and ran and ran. They actually broke the little treadmill in my lab because they ran so far. And you're giving it to them orally, or you're injecting it to them? It's a little tablet. They just put food in their food or something like that? Oh, the mice? Yeah. Oh, no. I thought you were talking about humans. In the mice, we put in their drinking water. Yeah, let's drink it. It's really easy. Wow. And they have no idea. No idea. And in fact, the people who are running the treadmill have no idea which is which. But we had mice running three kilometers, and then the machine stopped. And I get a text from the researcher. Hey, the machine broke. And I said, check the software. It turns out the software was written to stop at three kilometers because no mouse had run that far before. That's long. And those are old mice. Don't forget, these are mice that are the equivalent of a 65-year-old human. Really? Yeah. And we figured out why they run further. This isn't just try it and see. We figured out that the lining of the blood vessels needs NAD as you get older. Well, they need it all the time, but as you get older, you don't have enough NAD. So the NMN replenishes that and allows the blood vessel lining to respond to exercise and even grow blood vessels if you don't exercise. And so those mice, they ran and ran and ran. They didn't get lactate buildup as much. They just didn't feel tired. So they didn't have lactic acid buildup. Right. Wow. So muscle fatigue would be different. Well, they didn't seem to get that either. Wow. Just better blood flow. We even pinched off an artery and the body responded much better to restoring blood flow, which would be great for patients who have a heart attack. Whoa. Now, with human beings, what has been the most dramatic result? That's a hard question because a lot of it's early stage. We developed a molecule that seemed to effectively treat a disease called psoriasis, which is the inflammation. Yeah, Fennline, how's that? Yeah, so that worked. And that's a molecule that's... Is it something you apply to the skin? It was a pill, actually. Yeah. And how does that work? What is it doing? So it's an activator of one of these sirtuins that we found in yeast originally, these sirtuin protective enzymes in the body, and they're anti-inflammatory. And so it worked well against that disease. So psoriasis has something to do with inflammation? It is an inflammatory disorder, yeah. Are all autoimmune disorders, anti-inflammatory based disorders? I believe so. Really? Interesting. Hmm. Because I have vitiligo. You don't see the little spots on my skin where I don't have any pigment. It's genetic. My grandmother had it. My grandmother's sister had it. I wonder if that would help me. Yeah, I really couldn't say. What's it called again? Which one? The drug that was tested? Yeah. It has a name SRT-2104. And this is the stuff that worked on psoriasis? Yeah. In a small study in New York, yeah. Hmm. Now, what other things had really dramatic results on humans? Well, we're not there yet. We don't have dramatic results on humans. Is there anything promising results on humans? Are there NMN? Yes, there are. So this mTOR I mentioned earlier where the drug rapamycin, which is too dangerous to try on normal people, that drug has been tried on elderly people. And it boosted their immune system in the same way that you see with calorie-restricted mice. And so that was an early signal that you might be able to reverse aspects of aging in the elderly with that drug.